請問大家Statin起始後,多久檢驗一次肝指數?

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philip chen
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請問大家Statin起始後,多久檢驗一次肝指數?

文章 philip chen »

Statin起始後,4-6週驗GOT GPT?
之後沒6-12月驗一次?

Statin 的肝毒性,是dose-dependent? 或是使用時間長短?和水溶性、脂溶性有關?比較強的Rosuva Atorva 會比較產生肝毒性?

以上請教!


以下是爬文結果!
LFT should be carried out before and within 4-6 weeks of starting statin therapy (1). Thereafter at intervals of 6 months to 1 year - earlier if clinical features of hepatotoxicity; also at the first review at 4-6 weeks - enquire about adverse effects such as itching, rash, myalgia, arthralgia, insomnia (1)
if satisfactory lipid control and no evidence of adverse effects then review again at 4-6 months, then 6-12 monthly
if unsatisfactory lipid control then measurements should be repeated 6 weeks after dosage adjustments are made until the desired lipid concentrations are achieved (2)
however NICE state that LFTs only need to be measured on three occasions:
baseline liver enzymes should be measured before starting a statin. Liver function (transaminases) should be measured within 3 months of starting treatment and at 12 months, but not again unless clinically indicated
people who have liver enzymes (transaminases) that are raised but are less than 3 times the upper limit of normal should not be routinely excluded from statin therapy
treatment should be discontinued if serum transaminase concentrations rise to, and persist at, 3x normal range
monger
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註冊時間: 週二 1月 19, 2010 5:00 pm

Re: 請問大家Statin起始後,多久檢驗一次肝指數?

文章 monger »

我驗了
也被扣了
也去申付,爭議都沒回來
頭像
amin30
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註冊時間: 週五 10月 02, 2009 9:40 am
來自: 藍色星球一個小小小小島

Re: 請問大家Statin起始後,多久檢驗一次肝指數?

文章 amin30 »

審查要刪,就跟天要下雨,娘要嫁人一般無奈
莫聽穿林打葉聲,何妨吟嘯且徐行。
竹杖芒鞋輕勝馬,誰怕?一簑湮雨任平生。
Felix
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Re: 請問大家Statin起始後,多久檢驗一次肝指數?

文章 Felix »

monger 寫:我驗了
也被扣了
也去申付,爭議都沒回來
http://www.nhi.gov.tw/resource/bulletin ... %AE%9A.pdf

給一般老百姓看的文件:其中的處方規定,明白寫著"請注意副作用之產生如肝功能異常"
說得多好聽呀~~背後卻砍你一刀
再次證明G8G:善用兩面手法,習慣說假話
a7662888
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註冊時間: 週二 3月 30, 2010 11:55 pm

Re: 請問大家Statin起始後,多久檢驗一次肝指數?

文章 a7662888 »

FDA 已經改Label了
可以附上去看看申覆會不會過
http://www.fda.gov/drugs/drugsafety/ucm293101.htm

Monitoring Liver Enzymes

Labels have been revised to remove the need for routine periodic monitoring of liver enzymes in patients taking statins.
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